How Common Are False Negatives in NIPT (Non-Invasive Prenatal Testing)?
Learn about the rarity of false negatives in NIPT, factors influencing test accuracy, and when to consider follow-up diagnostic tests.
Video transcript
False negatives on NIPT (Non-Invasive Prenatal Testing) are rare, but they can occur. Accuracy rates for detecting common chromosomal abnormalities like Down syndrome are over 99%. Factors such as low fetal DNA fraction or maternal obesity might contribute to a false negative result. If results are of concern, follow up with diagnostic testing such as amniocentesis or chorionic villus sampling (CVS) for confirmation.
Questions and answers
What is the false negative rate for NIPT?
False negatives in NIPT are rare, with accuracy rates over 99% for common chromosomal abnormalities, although certain factors can lower reliability.
What factors can cause a false negative result in NIPT?
Low fetal DNA fraction in the mother's blood and maternal obesity are key factors that can contribute to false negative results in NIPT.
What should I do if I suspect a false negative NIPT result?
If there is concern about NIPT results, follow-up diagnostic testing such as amniocentesis or chorionic villus sampling (CVS) is recommended for confirmation.
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