Can I safely delete everything in my Downloads folder?

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Tags

1. #contents
2. #regularly
3. #downloads
4. #located
5. #installed
6. #update
7. #another
8. #folder
9. #deleted
10. #delete
11. #their
12. #application
13. #longer
14. #files
15. #installer
16. #review
17. #recommend
18. #users